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Robin Thorpe Selected Research

TGN-1412 (TGN1412)

8/2013Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release.
8/2011Comparison of novel methods for predicting the risk of pro-inflammatory clinical infusion reactions during monoclonal antibody therapy.
7/2011Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture.
12/2009Safety of biologics, lessons learnt from TGN1412.
9/2007"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.

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Robin Thorpe Research Topics

Disease

5Cytokine Release Syndrome
08/2013 - 09/2007
3Pure Red-Cell Aplasia
01/2016 - 05/2005
2Necrosis
08/2011 - 01/2010
1Infections
10/2017
1Multiple Sclerosis
11/2013
1Cardiovascular Diseases (Cardiovascular Disease)
06/2013
1Neoplasms (Cancer)
06/2013
1Colitis
09/2011
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
09/2011
1Autoimmune Polyendocrinopathies (Schmidt Syndrome)
05/2010
1Chronic Renal Insufficiency
01/2008
1Anemia
01/2008
1Inborn Genetic Diseases (Disease, Hereditary)
12/2007
1Wounds and Injuries (Trauma)
09/2005

Drug/Important Bio-Agent (IBA)

5TGN-1412 (TGN1412)IBA
08/2013 - 09/2007
4CytokinesIBA
09/2011 - 09/2005
3AntibodiesIBA
08/2011 - 01/2010
2Monoclonal AntibodiesIBA
01/2016 - 07/2011
2HematinicsIBA
01/2008 - 05/2005
1NucleophosminIBA
10/2017
1ErythropoietinFDA Link
01/2016
1Neutralizing AntibodiesIBA
11/2013
1Interleukin-2 (IL2)IBA
08/2013
1cadherin 5IBA
06/2013
1erucylphosphocholineIBA
06/2013
1Drinking WaterIBA
09/2011
1Polysaccharides (Glycans)IBA
09/2011
1XylansIBA
09/2011
1Transforming Growth Factors (Transforming Growth Factor)IBA
09/2011
1MucinsIBA
09/2011
1Interleukin-6 (Interleukin 6)IBA
08/2011
1Trastuzumab (Herceptin)FDA Link
08/2011
1Alemtuzumab (Campath)FDA Link
08/2011
1AutoantibodiesIBA
05/2010
1Interleukin-17 (Interleukin 17)IBA
05/2010
1Immune Sera (Antisera)IBA
05/2010
1Proteins (Proteins, Gene)FDA Link
01/2008

Therapy/Procedure

4Therapeutics
11/2013 - 12/2007
1Cell- and Tissue-Based Therapy (Cell Therapy)
06/2013